Memories are not written in stone: Re-writing fear memories by means of non-invasive brain stimulation and optogenetic manipulations

S Borgomaneri, S Battaglia, G Sciamanna… - Neuroscience & …, 2021 - Elsevier
The acquisition of fear associative memory requires brain processes of coordinated neural
activity within the amygdala, prefrontal cortex (PFC), hippocampus, thalamus and brainstem …

[HTML][HTML] The advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD research

TCM Bienvenu, C Dejean, D Jercog, B Aouizerate… - Neuron, 2021 - cell.com
Translational research on post-traumatic stress disorder (PTSD) has produced limited
improvements in clinical practice. Fear conditioning (FC) is one of the dominant animal …

Neural circuits underlying a psychotherapeutic regimen for fear disorders

J Baek, S Lee, T Cho, SW Kim, M Kim, Y Yoon, KK Kim… - Nature, 2019 - nature.com
A psychotherapeutic regimen that uses alternating bilateral sensory stimulation (ABS) has
been used to treat post-traumatic stress disorder. However, the neural basis that underlies …

[HTML][HTML] Memory trace for fear extinction: fragile yet reinforceable

Y Liu, S Ye, XN Li, WG Li - Neuroscience Bulletin, 2023 - Springer
Fear extinction is a biological process in which learned fear behavior diminishes without
anticipated reinforcement, allowing the organism to re-adapt to ever-changing situations …

Fear extinction learning improvement in PTSD after EMDR therapy: An fMRI study

PF Rousseau, M El Khoury-Malhame… - European Journal of …, 2019 - Taylor & Francis
ABSTRACT Objective: Neurobiological models of Posttraumatic Stress Disorder (PTSD)
implicate fear processing impairments in the maintenance of the disorder. Eye Movement …

[HTML][HTML] Role of the dorsal periaqueductal gray in posttraumatic stress disorder: mediation by dopamine and neurokinin

ML Brandão, TA Lovick - Translational psychiatry, 2019 - nature.com
In susceptible individuals, exposure to intensely traumatic life events can lead to the
development of posttraumatic stress disorder (PTSD), including long-term dysregulation of …

Cracking the EMDR code: Recruitment of sensory, memory and emotional networks during bilateral alternating auditory stimulation

PF Rousseau, S Boukezzi, R Garcia… - Australian & New …, 2020 - journals.sagepub.com
Introduction: The inability to extinguish a conditioned fear is thought to be at the core of post-
traumatic stress disorder. Eye movement desensitization and reprocessing therapy has …

Neurobiological correlates of EMDR therapy effect in PTSD

PF Rousseau, M El Khoury-Malhame… - European Journal of …, 2019 - Elsevier
Objective Posttraumatic stress disorder (PTSD) is a trouble that arises in the aftermath of a
traumatic event. The overwhelming resulting stressful memory can be desensitized by a brief …

[HTML][HTML] Effects of heart rate variability biofeedback during exposure to fear-provoking stimuli within spider-fearful individuals: Study protocol for a randomized …

SK Schäfer, FR Ihmig, KA Lara H, F Neurohr, S Kiefer… - Trials, 2018 - Springer
Background Specific phobias are among the most common anxiety disorders. Exposure
therapy is the treatment of choice for specific phobias. However, not all patients respond …

A systematic review evaluating PTSD treatment effects on intermediate phenotypes of PTSD.

AN Palmisano, S Meshberg-Cohen… - … , practice, and policy, 2023 - psycnet.apa.org
Objective: Although the efficacy of evidence-based treatments for posttraumatic stress
disorder (PTSD) has been well established, high rates of treatment dropout and/or …