Delayed healing and nonunion of fractures represent enormous burdens to patients and
healthcare systems. There are currently no approved pharmacological agents for the …

The bone-regenerative potentials of the periosteum have been explored as early as the 17th
century. Over the past few years, however, much has been discovered in terms of the …

Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in
chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that …

The complexity of fracture repair makes it an ideal process for studying the interplay
between the molecular, cellular, tissue, and organ level events involved in tissue …

Bone marrow mesenchymal stem cell (BMSC)-derived exosomes have been found to
enhance fracture healing. In addition, microRNAs contributing to the healing of various bone …

In order to solve the clinical challenges related to bone grafting, several tissue engineering
(TE) strategies have been proposed to repair critical-sized defects. Generally, the classical …

Like other tissue injuries, bone fracture triggers an inflammatory response, which plays an
important role in skeletal repair. Inflammation is believed to have both positive and negative …

Background Mice are increasingly used in fracture healing research because of the
opportunity to use transgenic animals. While both, male and female mice are employed …

The SOX family plays a vital role in determining the fate of cells and has garnered attention
in the fields of cancer research and regenerative medicine. It also shows promise in the …

Hippo signaling is modulated in response to cell density, external mechanical forces, and
rigidity of the extracellular matrix (ECM). The Mps one binder kinase activator (MOB) adaptor …