Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

The global epidemic of obesity is a major public health problem today. Obesity increases the
risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain …

The specific metabolic contribution of consuming different energy-yielding macronutrients
(namely, carbohydrates, protein and lipids) to obesity is a matter of active debate. In this …

DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …

Background Obesity is a multifactorial and chronic condition of growing universal concern. It
has recently been reported that bariatric surgery is a more successful treatment for severe …

Background One of the major challenges in obesity treatment is to explain the high
variability in the individual's response to specific dietary and physical activity interventions …

Diet, a modifiable risk factor, plays a pivotal role in most diseases, from cardiovascular
disease to type 2 diabetes mellitus, cancer, and obesity. However, our understanding of the …

Background The capacity of a polyphenol-enriched diet to modulate the epigenome in vivo
is partly unknown. Given the beneficial metabolic effects of a Mediterranean (MED) diet …

Background The high prevalence of obesity among US adults has resulted in significant
increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood …

Background Studies demonstrate the impact of diet and physical activity on epigenetic
biomarkers, specifically DNA methylation. However, no intervention studies have examined …