Epigenetics in human obesity and type 2 diabetes

C Ling, T Rönn - Cell metabolism, 2019 - cell.com
Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

Diagnosis of obesity and use of obesity biomarkers in science and clinical medicine

K Nimptsch, S Konigorski, T Pischon - Metabolism, 2019 - Elsevier
The global epidemic of obesity is a major public health problem today. Obesity increases the
risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain …

Contribution of macronutrients to obesity: implications for precision nutrition

R San-Cristobal, S Navas-Carretero… - Nature Reviews …, 2020 - nature.com
The specific metabolic contribution of consuming different energy-yielding macronutrients
(namely, carbohydrates, protein and lipids) to obesity is a matter of active debate. In this …

The potential of DNA methylation as a biomarker for obesity and smoking

A Heikkinen, S Bollepalli… - Journal of internal …, 2022 - Wiley Online Library
DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …

Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals

FR Talukdar, DI Escobar Marcillo, RS Laskar… - Clinical …, 2022 - Springer
Background Obesity is a multifactorial and chronic condition of growing universal concern. It
has recently been reported that bariatric surgery is a more successful treatment for severe …

DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

M Keller, A Yaskolka Meir, SH Bernhart, Y Gepner… - Genome medicine, 2020 - Springer
Background One of the major challenges in obesity treatment is to explain the high
variability in the individual's response to specific dietary and physical activity interventions …

Decoding the Foodome: Molecular Networks Connecting Diet and Health

G Menichetti, AL Barabási… - Annual review of nutrition, 2024 - annualreviews.org
Diet, a modifiable risk factor, plays a pivotal role in most diseases, from cardiovascular
disease to type 2 diabetes mellitus, cancer, and obesity. However, our understanding of the …

[HTML][HTML] A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial

A Hoffmann, AY Meir, T Hagemann, P Czechowski… - Metabolism, 2023 - Elsevier
Background The capacity of a polyphenol-enriched diet to modulate the epigenome in vivo
is partly unknown. Given the beneficial metabolic effects of a Mediterranean (MED) diet …

Epigenome-wide association study of metabolic syndrome in African-American adults

T Akinyemiju, AN Do, A Patki, S Aslibekyan, D Zhi… - Clinical …, 2018 - Springer
Background The high prevalence of obesity among US adults has resulted in significant
increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood …

Impact of a diet and activity health promotion intervention on regional patterns of DNA methylation

E Hibler, L Huang, J Andrade, B Spring - Clinical Epigenetics, 2019 - Springer
Background Studies demonstrate the impact of diet and physical activity on epigenetic
biomarkers, specifically DNA methylation. However, no intervention studies have examined …