Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil
Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
Cardiovascular disease (CVD) continues to be the primary cause of global mortality.
Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and …
Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and …
[HTML][HTML] Extracellular matrix stiffness and TGFβ2 regulate YAP/TAZ activity in human trabecular meshwork cells
Primary open-angle glaucoma progression is associated with increased human trabecular
meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in …
meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in …
Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathway
YC Wang, Q Chen, JM Luo, J Nie, QH Meng… - … & molecular medicine, 2019 - nature.com
The goals of this study were to investigate the role of the Notch1/PDGFRβ/ROCK1 signaling
pathway in the pathogenesis of pulmonary fibrosis and to explore the possibility of treating …
pathway in the pathogenesis of pulmonary fibrosis and to explore the possibility of treating …
The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix
M Matsuda, E Seki - Food and Chemical Toxicology, 2020 - Elsevier
Liver fibrosis is a hepatic wound-healing response caused by chronic liver diseases that
include viral hepatitis, alcoholic liver disease, non-alcoholic steatohepatitis, and cholestatic …
include viral hepatitis, alcoholic liver disease, non-alcoholic steatohepatitis, and cholestatic …
Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia
T Ashino, M Yamamoto, T Yoshida… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Reactive oxygen species are important mediators for platelet-derived growth
factor (PDGF) signaling in vascular smooth muscle cells, whereas excess reactive oxygen …
factor (PDGF) signaling in vascular smooth muscle cells, whereas excess reactive oxygen …
Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization
A Strzelecka-Kiliszek, S Mebarek… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Abstract Background Members of Rho-associated coiled-coil kinases (ROCKs) are effectors
of Rho family of small GTPases. ROCKs have multiple functions that include regulation of …
of Rho family of small GTPases. ROCKs have multiple functions that include regulation of …
miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis
K Chen, H He, Y Xie, L Zhao, S Zhao, X Wan, W Yang… - Scientific reports, 2015 - nature.com
Multiple symmetric lipomatosis (MSL) is a rare disease characterized by symmetric and
abnormal distribution of subcutaneous adipose tissue (SAT); however, the etiology is largely …
abnormal distribution of subcutaneous adipose tissue (SAT); however, the etiology is largely …
Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues
M Iizuka, K Kimura, S Wang, K Kato… - Cell structure and …, 2012 - jstage.jst.go.jp
The small GTP-binding protein Rho plays a crucial role in a wide variety of cellular functions
through various effector proteins. Rho-kinase is a key effector protein of Rho, which is …
through various effector proteins. Rho-kinase is a key effector protein of Rho, which is …
Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK …
Y Cui, YW Sun, HS Lin, WM Su, Y Fang, Y Zhao… - Molecular and cellular …, 2014 - Springer
Matrix metalloproteinases (MMP) play a pivotal role in the pathogenesis of cardiovascular
diseases. Their expressions are altered in response to a variety of stimuli, including growth …
diseases. Their expressions are altered in response to a variety of stimuli, including growth …