[HTML][HTML] Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
OS Johansen, T Ma, JB Hansen, LK Markussen… - Cell, 2021 - cell.com
Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism
H Takahashi, CRR Alves, KI Stanford… - Nature …, 2019 - nature.com
Exercise improves health and well-being across diverse organ systems, and elucidating
mechanisms underlying the beneficial effects of exercise can lead to new therapies. Here …
mechanisms underlying the beneficial effects of exercise can lead to new therapies. Here …
The role of autophagy in brown and beige adipose tissue plasticity
M Cairó, J Villarroya - Journal of physiology and biochemistry, 2020 - Springer
Since the rediscovery of active brown and beige adipose tissues in humans a decade ago,
great efforts have been made to identify the mechanisms underlying the activation and …
great efforts have been made to identify the mechanisms underlying the activation and …
Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages
Single-cell RNA sequencing (scRNA-seq) enables molecular characterization of complex
biological tissues at high resolution. The requirement of single-cell extraction, however …
biological tissues at high resolution. The requirement of single-cell extraction, however …
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
Abstract Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown
adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we …
adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we …
Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes
R Kriszt, S Arai, H Itoh, MH Lee, AG Goralczyk… - Scientific Reports, 2017 - nature.com
The identification of brown adipose deposits in adults has led to significant interest in
targeting this metabolically active tissue for treatment of obesity and diabetes. Improved …
targeting this metabolically active tissue for treatment of obesity and diabetes. Improved …
Optical diffraction tomography and Raman spectroscopy reveal distinct cellular phenotypes during white and brown adipocyte differentiation
White adipose tissue (WAT) and brown adipose tissue (BAT) are the primary types of fats in
humans, and they play prominent roles in energy storage and thermogenesis, respectively …
humans, and they play prominent roles in energy storage and thermogenesis, respectively …
[HTML][HTML] Nanosecond SRS fiber amplifier for label-free near-infrared photoacoustic microscopy of lipids
Near-infrared photoacoustics receives increasing interest as an intravital modality to sense
key biomolecules. One of the most central types of biomolecules of interest are lipids as they …
key biomolecules. One of the most central types of biomolecules of interest are lipids as they …
Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover
Aims/hypothesis PPARGC1A encodes peroxisome proliferator-activated receptor γ
coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial …
coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial …
Fructose vs. glucose: modulating stem cell growth and function through sugar supplementation
In multicellular organisms, stem cells are impacted by microenvironmental resources such
as nutrient availability and oxygen tension for their survival, growth, and differentiation …
as nutrient availability and oxygen tension for their survival, growth, and differentiation …