Ribosomally synthesized and post-translationally modified peptides (RiPPs) display a
diverse range of structures and continue to expand as a natural product class. Accordingly …

Pyrroloquinoline quinone (PQQ) is a peptide-derived redox cofactor produced by
prokaryotes that also plays beneficial roles in organisms from other kingdoms. We review …

The radical S-adenosylmethionine (SAM) protein PqqE is predicted to function in the
pyrroloquinoline quinone (PQQ) biosynthetic pathway via catalysis of carbon-carbon bond …

The widely distributed, essential redox factor pyrroloquinoline quinone (PQQ, methoxatin)(1)
was discovered in the mid-1960s. The breadth and depth of its biological effects are steadily …

Understanding the relationship between the metallocofactor and its protein environment is
the key to uncovering the mechanism of metalloenzymes. PqqE, a radical S …

Mycofactocin is a putative redox cofactor and is classified as a ribosomally synthesized and
post-translationally modified peptide (RiPP). Some RiPP natural products, including …

Biosynthesis of the ribosomally synthesized and post-translationally modified peptide
(RiPP), pyrroloquinoline quinone (PQQ), is initiated when the precursor peptide, PqqA, is …

The Radical SAM (RS) enzyme PqqE catalyzes the first step in the biosynthesis of the
bacterial cofactor pyrroloquinoline quinone, forming a new carbon–carbon bond between …

Apd1, a cytosolic yeast protein, and Aim32, its counterpart in the mitochondrial matrix, have
a C-terminal thioredoxin-like ferredoxin (TLF) domain and a widely divergent N-terminal …

According to the classic definition of aging we share, it is a combination of changes in an
organism leading to an increase in the probability of its death (rate of mortality). 1–4 It should …