Plasmonic nanocavities are able to engineer and confine electromagnetic fields to
subwavelength volumes. In the past decade, they have enabled a large set of applications …

Single-molecule FRET (smFRET) has become a mainstream technique for studying
biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by …

Obtaining sequential and conformational information on proteins is vital to understand their
functions. Although the nanopore-based electrical detection can sense single molecule (SM) …

Single molecule fluorescence spectroscopy is at the heart of molecular biophysics research
and the most sensitive biosensing assays. The growing demand for precision medicine and …

Metasurfaces have revolutionized optical biosensing and diagnostic assays due to their
sensitivity, compactness, and label-free operation. However, metasurface applications in …

Using the ultraviolet autofluorescence of tryptophan amino acids offers fascinating
perspectives to study single proteins without the drawbacks of fluorescence labeling …

The fundamental understanding of molecular quantum electrodynamics via the strong light–
matter interactions between a nanophotonic cavity and quantum emitters opens various …

Single-molecule fluorescence techniques have revolutionized our ability to study proteins.
However, the presence of a fluorescent label can alter the protein structure and/or modify its …

Proteins have been considered key building blocks of life. In particular, the protein content of
an organism and a cell offers significant information for the in-depth understanding of the …

Fluorescence-based single-molecule optical detection techniques are widely chosen over
other methods, owing to the ease of background screening and better signal-to-noise …