Proteomics of the Heart

OA Karpov, A Stotland, K Raedschelders… - Physiological …, 2024 - journals.physiology.org
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

Integrative proteomic and metabolomic elucidation of cardiomyopathy with in vivo and in vitro models and clinical samples

Y Hu, Y Zou, L Qiao, L Lin - Molecular Therapy, 2024 - cell.com
Cardiomyopathy is a prevalent cardiovascular disease that affects individuals of all ages
and can lead to life-threatening heart failure. Despite its variety in types, each with distinct …

Empagliflozin protects against heart failure with preserved ejection fraction partly by inhibiting the senescence-associated STAT1–STING axis

Y Shi, L Zhao, J Wang, X Liu, Y Bai, H Cong… - Cardiovascular …, 2024 - Springer
Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without
effective therapies. Empagliflozin (EMPA) improves cardiovascular outcomes in HFpEF …

Myocardial metabolic reprogramming in HFpEF

Z Zhang, M Sun, W Jiang, L Yu, C Zhang… - Journal of Cardiovascular …, 2024 - Springer
Heart failure (HF) caused by structural or functional cardiac abnormalities is a significant
cause of morbidity and mortality worldwide. While HF with reduced ejection fraction (HErEF) …

Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension

JH Berger, Y Shi, TR Matsuura, K Batmanov, X Chen… - Scientific Reports, 2025 - nature.com
Heart failure with preserved ejection fraction (HFpEF) is increasingly common but its
pathogenesis is poorly understood. The ability to assess genetic and pharmacologic …

Beyond weight loss: the potential of glucagon-like peptide-1 receptor agonists for treating heart failure with preserved ejection fraction

TY Wang, Q Yang, XY Cheng, JC Ding, PF Hu - Heart Failure Reviews, 2025 - Springer
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with
various phenotypes, and obesity is one of the most common and clinically relevant …

Multi‐omic analyses and network biology in cardiovascular disease

CJ Reitz, U Kuzmanov, AO Gramolini - Proteomics, 2023 - Wiley Online Library
Heart disease remains a leading cause of death in North America and worldwide. Despite
advances in therapies, the chronic nature of cardiovascular diseases ultimately results in …

Effect of Zoapatle (Montanoa tomentosa) on Inflammatory Markers in a Murine Model of Ventricular Hypertrophy

CE López-Luna, C Vargas-De-León… - Scientia …, 2024 - mdpi.com
Zoapatle, a native plant utilized for centuries in traditional Mexican medicine, is abundantly
found in Mesoamerica and northern South America. Pleiotropic effects of this genus have …

[PDF][PDF] The role of endosarcomeric cytoskeleton proteins in the mechanisms of left ventricular diastolic dysfunction: fofocus on titin

V Kalyuzhin, A Teplyakov, I Bespalova… - Бюллетень …, 2023 - researchgate.net
Recognizing the fact that isolated left ventricular (LV) diastolic dysfunction (DD) underlies
approximately 50% of all heart failure cases requires a deep understanding of its principal …

Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure

J Wang, X Zhu, S Wang, Y Zhang, W Hua… - Frontiers in …, 2023 - frontiersin.org
Background: Post-infarction chronic heart failure is the most common type of heart failure.
Patients with chronic heart failure show elevated morbidity and mortality with limited …