The adequate management of central nervous system (CNS) infections requires that
antimicrobial agents penetrate the blood–brain barrier (BBB) and achieve concentrations in …

Aminoglycosides are potent water-soluble antibiotics, with peak concentration-dependent
bactericidal activity against many pathogenic aerobic Gram-negative bacilli and …

Many Pseudomonas aeruginosa isolates from the airways of patients with cystic fibrosis (CF)
are sensitive to antibiotics in susceptibility testing, but eradication of the infection is difficult …

A large amount of new information about the PAE has been generated over the past 15 yr.
We know how the presence or absence of a PAE varies for different antibiotics and micro …

The postantibiotic effect (PAE) refers to a period of time after complete removal of an
antimicrobial during which there is no growth of the target organism. The PAE appears to be …

Rifampin has clinical efficacy against a wide variety of organisms, including Staphylococcus
aureus, Legionella pneumophila, group A Streptococcus, Brucella sp, Haemophilus …

To evaluate the rationale behind dosing aminoglycosides as a single daily dose versus
traditional dosing approaches, we conducted a MEDLINE search to identify all pertinent …

The genus Klebsiella consists of non-motile, aerobic and facultatively anaerobic, Gram
negative rods. At the time of writing, the genus Klebsiella comprises K. pneumoniae subsp …

Objective: The efficacy of ivermectin pour on formulation (Ivomec pour on) against
gastrointestinal nematodiasis in cattle (Bos indicus), its effect on the blood parameters and …

The postantibiotic effects (PAEs) OF 16 antibiotics or antibiotic combinations currently used
against Burkholderia (Pseudomonas) pseudomallei were determined. The beta-lactams had …