The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure
that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Tuberculosis remains a fatal disease caused by Mycobacterium tuberculosis, which contains
various unique components that affect the host immune system. Trehalose-6, 6′-dimycolate …

The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …

Mycobacterium species, including the human pathogen Mycobacterium tuberculosis, are
unique among Gram-positive bacteria in producing a complex cell wall that contains …

Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Various C-type lectin receptors (CLRs), including Mincle and Dectin-2, function as pattern
recognition receptors and play a central role in immunity to fungal pathogens. However, the …

The cell wall is a major virulence factor of Mycobacterium tuberculosis and contributes to its
intrinsic drug resistance. Recently, cryo-electron microscopy showed that mycobacterial cell …

The re-emergence of tuberculosis in its present-day manifestations–single, multiple and
extensive drug-resistant forms and as HIV-TB coinfections–has resulted in renewed …