The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

The global emergence of carbapenemase-producing bacteria capable of hydrolyzing the
once effective carbapenem antibiotics is considered a contemporary public health concern …

Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

In this review, we summarize the current “state of the art” of carbapenem antibiotics and their
role in our antimicrobial armamentarium. Among the β-lactams currently available …

The spread of Enterobacteriaceae, primarily Klebsiella pneumoniae, producing KPC, VIM,
IMP, and NDM carbapenemases, is causing an unprecedented public health crisis …

Abstract OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly
reported in enterobacterial species. To date, six OXA-48-like variants have been identified …

ABSTRACT A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a
urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that …

Despite being members of gut microbiota, Enterobacteriaceae are associated with many
severe infections such as bloodstream infections. The β-lactam drugs have been the …