[HTML][HTML] Virtual staining, segmentation, and classification of blood smears for label-free hematology analysis

E RoblesFrancisco - BME frontiers, 2022 - spj.science.org
Abstract Objective and Impact Statement. We present a fully automated hematological
analysis framework based on single-channel (single-wavelength), label-free deep-ultraviolet …

Compact and low-cost deep-ultraviolet microscope system for label-free molecular imaging and point-of-care hematological analysis

V Gorti, N Kaza, EK Williams, WA Lam… - Biomedical Optics …, 2023 - opg.optica.org
Deep-ultraviolet (UV) microscopy enables label-free, high-resolution, quantitative molecular
imaging and enables unique applications in biomedicine, including the potential for fast …

X-ray crystallography and sickle cell disease drug discovery—a tribute to Donald Abraham

AK Donkor, PP Pagare, MHAL Mughram… - Frontiers in Molecular …, 2023 - frontiersin.org
X-ray crystallography and structure-based drug discovery have played a major role in the
discovery of antisickling agents that target hemoglobin (Hb) for the treatment of sickle cell …

Label-free deep-UV microscopy detection and grading of neutropenia using a passive microfluidic device

A Ojaghi, E Kendall Williams, N Kaza, V Gorti, H Choi… - Optics Letters, 2022 - opg.optica.org
Neutropenia is a condition comprising an abnormally low number of neutrophils, a type of
white blood cell, which puts patients at an increased risk of severe infections. Neutropenia is …

Label‐free single‐shot imaging with on‐axis phase‐shifting holographic reflectance quantitative phase microscopy

H Liu, X Wu, G Liu, H Ren, V RV… - Journal of …, 2022 - Wiley Online Library
Quantitative phase microscopy (QPM) has been emerged as an indispensable diagnostic
and characterization tool in biomedical imaging with its characteristic nature of label‐free …

Label-free hematology analysis method based on defocusing phase-contrast imaging under illumination of 415 nm light

D Chen, N Li, X Liu, S Zeng, X Lv, L Chen… - Biomedical Optics …, 2022 - opg.optica.org
Label-free imaging technology is a trending way to simplify and improve conventional
hematology analysis by bypassing lengthy and laborious staining procedures. However, the …

Multiparameter mobile blood analysis for complete blood count using contrast-enhanced defocusing imaging and machine vision

D Chen, N Li, S Zeng, X Lv, L Chen, X Liu, Q Hu - Analyst, 2023 - pubs.rsc.org
Blood analysis through complete blood count is the most basic medical test for disease
diagnosis. Conventional blood analysis requires bulky and expensive laboratory facilities …

Quantifying UV-induced photodamage for longitudinal live-cell imaging applications of deep-UV microscopy

V Gorti, K McCubbins, D Houston… - Biomedical Optics …, 2024 - opg.optica.org
Deep-UV microscopy enables high-resolution, label-free molecular imaging by leveraging
biomolecular absorption properties in the UV spectrum. Recent advances in UV-imaging …

Reflectional quantitative differential phase microscopy using polarized wavefront phase modulation

Y Ma, T Dai, L Yu, L Ma, S An, Y Wang… - Journal of …, 2023 - Wiley Online Library
Quantitative phase microscopy (QPM), as a label‐free and nondestructive technique, has
been playing an indispensable tool in biomedical imaging and industrial inspection. Herein …

Biothermodynamics of Hemoglobin and Red Blood Cells: Analysis of Structure and Evolution of Hemoglobin and Red Blood Cells, Based on Molecular and Empirical …

ME Popović, M Stevanović… - Journal of Molecular …, 2024 - Springer
Hemoglobin and red blood cells (erythrocytes) have been studied extensively from the
perspective of life and biomedical sciences. However, no analysis of hemoglobin and red …