Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

S Qian, O Golubnitschaja, X Zhan - Epma Journal, 2019 - Springer
A strong relationship exists between tumor and inflammation, which is the hot point in cancer
research. Inflammation can promote the occurrence and development of cancer by …

Toward a complete cure for chronic hepatitis B: Novel therapeutic targets for hepatitis B virus

SW Kim, JS Yoon, M Lee, Y Cho - Clinical and molecular …, 2021 - pmc.ncbi.nlm.nih.gov
Hepatitis B virus (HBV) affects approximately 250 million patients worldwide, resulting in the
progression to cirrhosis and hepatocellular carcinoma, which are serious public health …

[PDF][PDF] Longitudinal assessment of three serum biomarkers to detect very early‐stage hepatocellular carcinoma

J Choi, GA Kim, S Han, W Lee, S Chun, YS Lim - Hepatology, 2019 - Wiley Online Library
We aimed to determine the surveillance performance of alpha‐fetoprotein (AFP), lectin‐
reactive AFP (AFP‐L3), des‐gamma‐carboxy prothrombin (DCP), and their combinations for …

Circulating HBV RNA: from biology to clinical applications

R Deng, S Liu, S Shen, H Guo, J Sun - Hepatology, 2022 - Wiley Online Library
Chronic HBV infection can hardly be cured due to the persistence of an intrahepatic pool of
viral covalently closed circular DNA (cccDNA) transcription template, which is refractory to …

Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1

M Zhu, Z Liang, J Pan, X Zhang, R Xue, G Cao… - … Therapy-Nucleic Acids, 2021 - cell.com
Hepatitis B virus (HBV) produces circular RNA (circRNA), whose functions have not yet been
clearly elucidated. In this study, a novel circRNA HBV_circ_1 produced by HBV was …

Characterization of a novel capsid assembly modulator for the treatment of chronic hepatitis b virus infection

D Burdette, A Hyrina, Z Song, RK Beran… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
The standard of care for the treatment of chronic hepatitis B (CHB) is typically lifelong
treatment with nucleos (t) ide analogs (NAs), which suppress viral replication and provide …

Pathogenesis of viral hepatitis-induced chronic liver disease: role of extracellular vesicles

HK Lim, GP Jeffrey, GA Ramm… - Frontiers in cellular and …, 2020 - frontiersin.org
Extracellular vesicles are encapsulated lipid nanoparticles secreted by a variety of cell types
in living organisms. They are known to carry proteins, metabolites, nucleic acids, and lipids …

[PDF][PDF] Pevonedistat, a neuronal precursor cell‐expressed developmentally down‐regulated protein 8–activating enzyme inhibitor, is a potent inhibitor of hepatitis B …

K Sekiba, M Otsuka, M Ohno, M Yamagami… - …, 2019 - Wiley Online Library
Hepatitis B virus (HBV) infection is a major health concern worldwide. To prevent HBV‐
related mortality, elimination of viral proteins is considered the ultimate goal of HBV …

The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis

F Kong, H You, D Kong, K Zheng, R Tang - Virology journal, 2019 - Springer
Background The ubiquitin proteasome system (UPS) regulates the expression levels of
cellular proteins by ubiquitination of protein substrates followed by their degradation via the …

Role of m6A RNA methylation in the development of hepatitis B virus‐associated hepatocellular carcinoma

C Zhang, D Dai, W Zhang, W Yang… - Journal of …, 2022 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most common liver malignancy that can be
developed from hepatitis B and cirrhosis. Many pathophysiological alterations, including …