Structure, function, and pharmacology of glutamate receptor ion channels

KB Hansen, LP Wollmuth, D Bowie, H Furukawa… - Pharmacological …, 2021 - ASPET
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins

IH Greger, JF Watson, SG Cull-Candy - Neuron, 2017 - cell.com
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes

J Schwenk, N Harmel, A Brechet, G Zolles, H Berkefeld… - Neuron, 2012 - cell.com
AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the
mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or …

Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain

J Schwenk, D Baehrens, A Haupt, W Bildl, S Boudkkazi… - Neuron, 2014 - cell.com
Native AMPA receptors (AMPARs) in the mammalian brain are macromolecular complexes
whose functional characteristics vary across the different brain regions and change during …

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition

J Yu, P Rao, S Clark, J Mitra, T Ha, E Gouaux - Nature, 2021 - nature.com
AMPA-selective glutamate receptors mediate the transduction of signals between the
neuronal circuits of the hippocampus. The trafficking, localization, kinetics and …

Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2

SP Gangwar, LY Yen, MV Yelshanskaya… - Nature Structural & …, 2023 - nature.com
Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …

AMPA receptor structure and auxiliary subunits

A Kamalova, T Nakagawa - The Journal of physiology, 2021 - Wiley Online Library
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking

D Bissen, F Foss, A Acker-Palmer - Cellular and Molecular Life Sciences, 2019 - Springer
To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8

B Herguedas, JF Watson, H Ho, O Cais, J García-Nafría… - Science, 2019 - science.org
INTRODUCTION Neuronal communication at excitatory synapses in the brain involves
release of the neurotransmitter l-glutamate from the presynapse of one cell and its detection …

An ER assembly line of AMPA-receptors controls excitatory neurotransmission and its plasticity

J Schwenk, S Boudkkazi, MK Kocylowski, A Brechet… - Neuron, 2019 - cell.com
Excitatory neurotransmission and its activity-dependent plasticity are largely determined by
AMPA-receptors (AMPARs), ion channel complexes whose cell physiology is encoded by …