Bacterial pore-forming toxins induce a rapid and massive increase in cytosolic Ca2+
concentration due to the formation of pores in the plasma membrane and/or activation of …

The nuclear factor of activated T cells (NFAT) was first identified as a transcriptional
regulator of activated T cells. The NFAT family is involved in the development of tumors …

Maintenance of adult tissues depends on stem cell self-renewal in local niches.
Spermatogonial stem cells (SSC) are germline adult stem cells necessary for …

We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative
stress. Subsequently, numerous studies have indicated the potential applications of H2 in …

Anginosus group streptococci (AGS) are opportunistic human pathogens of the oral cavity.
The β-hemolytic subgroup of Streptococcus anginosus subsp. anginosus secretes …

The essential first step in bacterial colonization is adhesion to the host epithelial cells. The
early host-responses post-bacterial adhesions are still poorly understood. Early growth …

The genus Streptococcus infects a broad range of hosts, including humans. Some species,
such as S. pyogenes, S. agalactiae, S. pneumoniae, and S. mutans, are recognized as the …

Infection with Streptococcus pneumoniae causes over 150,000 cases of pneumonia
annually in the United States alone. We performed a meta-analysis of publicly available …

Streptococcus mitis strain Nm-65 secretes an atypical 5-domain-type cholesterol-dependent
cytolysin (CDC) called S. mitis-derived human platelet aggregation factor (Sm-hPAF) …

肝损伤是多因素引起的复杂病理生理变化, 早期生长转录因子-1 (EGR-1) 在肝损伤中的利弊作用
目前仍存在争议. 相关研究证实在半乳糖胺/脂多糖诱导的急性肝损伤和异硫氰酸酯(ANIT) …