Protein O-GlcNAcylation: emerging mechanisms and functions
O-GlcNAcylation—the attachment of O-linked N-acetylglucosamine (O-GlcNAc) moieties to
cytoplasmic, nuclear and mitochondrial proteins—is a post-translational modification that …
cytoplasmic, nuclear and mitochondrial proteins—is a post-translational modification that …
Nutrient regulation of signaling and transcription
GW Hart - Journal of Biological Chemistry, 2019 - ASBMB
In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …
surfaces of living cells in the murine immune system, we discovered a novel form of …
Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase
Abstract O-linked N-acetylglucosamine (O-GlcNAc) is an essential and dynamic post-
translational modification that is presented on thousands of nucleocytoplasmic proteins …
translational modification that is presented on thousands of nucleocytoplasmic proteins …
Targeting O-GlcNAcylation to develop novel therapeutics
Y Zhu, GW Hart - Molecular aspects of medicine, 2021 - Elsevier
O-linked β-DN-acetylglucosamine (O-GlcNAc) is an abundant post-translational modification
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
O-GlcNAc as an integrator of signaling pathways
O-GlcNAcylation is an important posttranslational modification governed by a single pair of
enzymes–O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes …
enzymes–O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes …
The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells?
ZG Levine, S Walker - Annual review of biochemistry, 2016 - annualreviews.org
O-linked N-acetylglucosamine transferase (OGT) is found in all metazoans and plays an
important role in development but at the single-cell level is only essential in dividing …
important role in development but at the single-cell level is only essential in dividing …
O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy
Q Lu, X Zhang, T Liang, X Bai - Molecular Medicine, 2022 - Springer
O-linked β-dN-acetylglucosamine (O-GlcNAc) is an important post-translational modification
of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all …
of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all …
Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode
Abstract Human O-GlcNAcase (hOGA) is the unique enzyme responsible for the hydrolysis
of the O-linked β-N-acetyl glucosamine (O-GlcNAc) modification, an essential protein …
of the O-linked β-N-acetyl glucosamine (O-GlcNAc) modification, an essential protein …