Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor
necrosis factor family mediate this process. They either assist persistent viral infection or …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

Intrinsic (innate) and acquired (adaptive) resistance to chemotherapy critically limits the
outcome of cancer treatments. For many years, it was assumed that the interaction of a drug …

Out of the almost 17 members of the TNF superfamily, TNF is probably the most potent
inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms …

Chronic infection with the hepatitis C virus (HCV) is a major risk factor for the development of
hepatocellular carcinoma (HCC) worldwide. The pathogenesis of HCC in HCV infection has …

Tumor necrosis factor-α (TNF-α) functions as a two-edged sword in the liver. TNF-α is
required for normal hepatocyte proliferation during liver regeneration. It functions both as a …

Hepatitis C was first recognized as a distinct form of liver disease in the mid-1970s with the
advent of diagnostic tests for hepatitis A and B virus infection (A LTER et al. 1975; P RINCE …

The development of hepatocellular carcinoma (HCC) is a multistep process associated with
changes in host gene expression, some of which correlate with the appearance and …

The core protein of hepatitis C virus (HCV) is believed to form the capsid shell of virus
particles. Maturation of the protein is achieved through cleavage by host cell proteases to …

The immune response to viral antigens is thought to be responsible for viral clearance and
disease pathogenesis during hepatitis C virus (HCV) infection. In chronically infected …