Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

Exosomes mediate cell-to-cell crosstalk involving a variety of biomolecules through an
intricate signaling network. In recent years, the pivotal role of exosomes and their non …

Cancer is one of the most important health problems and the second leading cause of death
worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to …

The current diagnosis and treatment of sarcoma continue to show limited timeliness and
efficacy. In order to enable the early detection and management of sarcoma, increasing …

Hypoxia develops during the growth of solid tumors and influences tumoral activity in
multiple ways. Low oxygen tension is also present in the bone microenvironment where …

Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1
(DAX1) is an orphan nuclear receptor encoded by the NR0B1 gene. The functional study …

Ewing sarcoma (ES) is an extremely aggressive pediatric tumor primarily propelled by the
EWS:: FLI1 fusion protein. This fusion protein plays a pivotal role in various biological …

Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including
osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are …

Ewing's sarcoma (ES) is a pediatric sarcoma caused by a chromosomal translocation.
Unlike in most cancers, the genomes of ES patients are very stable. The translocation …