Epigenetic regulation of innate immune dynamics during inflammation

BA Caldwell, L Li - Journal of leukocyte biology, 2024 - academic.oup.com
Innate immune cells play essential roles in modulating both immune defense and
inflammation by expressing a diverse array of cytokines and inflammatory mediators …

Role of Trained Immunity in Heath and Disease

S Das, KJ Lavine - Current Cardiology Reports, 2025 - Springer
Abstract Purpose of Review This review aims to explore the role of immune memory and
trained immunity, focusing on how innate immune cells like monocytes, macrophages, and …

Hypothesis: hematogenous metastatic cancer cells of solid tumors may disguise themselves as memory macrophages for metastasis

C Jiang, J Wu - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
German pathologist Otto Aichel suggested, a century ago, that the cancer cell acquired its
metastatic property from a leukocyte via cell-cell fusion. Since then, several revised versions …

Immunoresponsive gene 1 facilitates TLR4 agonist-induced augmentation of innate antimicrobial immunity

MA McBride, KR Caja, TK Patil… - Journal of Leukocyte …, 2024 - academic.oup.com
Abstract Treatment with the toll-like receptor 4 agonist monophosphoryl lipid A conditions
innate immunocytes to respond robustly to subsequent infection, a phenotype termed innate …

Trained Immunity Enhances Host Resistance to Infection in Aged Mice

D Hao, KR Caja, MA McBride, AM Owen… - Journal of Leukocyte …, 2024 - academic.oup.com
Aging significantly increases the incidence and severity of infections, with individuals aged
65 and above accounting for 65% of sepsis cases. Innate immune training, known as …

[HTML][HTML] Lung Immunity to Fungal Infections by Macrophages: Mechanisms and Implications

J Sharma, NA Kulkarni… - … -Molecular Pathways and …, 2024 - intechopen.com
Pulmonary pathogenic fungi cause severe to fatal disseminated infections, especially in
immunocompromised patients. Alveolar macrophages form an essential early innate cellular …

Lung Immunity to Fungal Infections by Macrophages: Mechanisms and Implications

SG Nanjappa - Macrophages-Molecular Pathways and …, 2024 - books.google.com
Pulmonary pathogenic fungi cause severe to fatal disseminated infections, especially in
immunocompromised patients. Alveolar macrophages form an essential early innate cellular …