Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Neutrophils in chronic inflammatory diseases

A Herrero-Cervera, O Soehnlein… - Cellular & molecular …, 2022 - nature.com
Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Neutrophil phenotypes and functions in cancer: A consensus statement

DF Quail, B Amulic, M Aziz, BJ Barnes… - Journal of Experimental …, 2022 - rupress.org
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Immunology of acute and chronic wound healing

K Raziyeva, Y Kim, Z Zharkinbekov, K Kassymbek… - Biomolecules, 2021 - mdpi.com
Skin wounds greatly affect the global healthcare system, creating a substantial burden on
the economy and society. Moreover, the situation is exacerbated by low healing rates, which …

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

JM Adrover, SAC McDowell, XY He, DF Quail… - Cancer Cell, 2023 - cell.com
Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

R Grieshaber-Bouyer, FA Radtke, P Cunin… - Nature …, 2021 - nature.com
Neutrophils are implicated in multiple homeostatic and pathological processes, but whether
functional diversity requires discrete neutrophil subsets is not known. Here, we apply single …

IL-4 and IL-13: regulators and effectors of wound repair

JE Allen - Annual review of immunology, 2023 - annualreviews.org
Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

Chronic diabetic wounds and their treatment with skin substitutes

J Holl, C Kowalewski, Z Zimek, P Fiedor, A Kaminski… - Cells, 2021 - mdpi.com
With the global prevalence of type 2 diabetes mellitus steeply rising, instances of chronic,
hard-healing, or non-healing diabetic wounds and ulcers are predicted to increase. The …

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

A Lagnado, J Leslie, MH Ruchaud‐Sparagano… - The EMBO …, 2021 - embopress.org
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐
inflammatory phenotype, thought to contribute to aging and age‐related diseases …