[HTML][HTML] Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

A Ramachandran, RGJ Visschers, L Duan… - Journal of clinical and …, 2018 - ncbi.nlm.nih.gov
Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Mitochondrial abnormalities—a link to idiosyncratic drug hepatotoxicity?

UA Boelsterli, PLK Lim - Toxicology and applied pharmacology, 2007 - Elsevier
Idiosyncratic drug-induced liver injury (DILI) is a major clinical problem and poses a
considerable challenge for drug development as an increasing number of successfully …

Non-antibiotic pharmaceuticals enhance the transmission of exogenous antibiotic resistance genes through bacterial transformation

Y Wang, J Lu, J Engelstädter, S Zhang, P Ding… - The ISME …, 2020 - academic.oup.com
Antibiotic resistance is a serious global threat for public health. Considering the high
abundance of cell-free DNA encoding antibiotic resistance genes (ARGs) in both clinical …

A human hepatocellular in vitro model to investigate steatosis

MJ Gómez-Lechón, MT Donato… - Chemico-biological …, 2007 - Elsevier
The present study was designed to define an experimental model of hepatocellular steatosis
with a fat overaccumulation profile in which the metabolic and cytotoxic/apoptotic effects …

Interaction of copper (II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA-and albumin-binding

F Dimiza, F Perdih, V Tangoulis, I Turel… - Journal of inorganic …, 2011 - Elsevier
Copper (II) complexes with the non-steroidal anti-inflammatory drugs (NSAIDs) naproxen
and diclofenac have been synthesized and characterized in the presence of nitrogen donor …

[HTML][HTML] Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

SH Jung, W Lee, SH Park, KY Lee, YJ Choi, S Choi… - Redox Biology, 2020 - Elsevier
Abstract Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with
various side effects, including cardiovascular and hepatic disorders. Studies suggest that …

Mechanism of mitochondrial uncouplers, inhibitors, and toxins: focus on electron transfer, free radicals, and structure-activity relationships

P Kovacic, RS Pozos, R Somanathan… - Current medicinal …, 2005 - ingentaconnect.com
The biology of the mitochondrial electron transport chain is summarized. Our approach to
the mechanism of uncouplers, inhibitors, and toxins is based on electron transfer (ET) and …

Cinnamon aqueous extract attenuates diclofenac sodium and oxytetracycline mediated hepato-renal toxicity and modulates oxidative stress, cell apoptosis, and …

GE Elshopakey, ST Elazab - Veterinary Sciences, 2021 - mdpi.com
Among commonly consumed anti-inflammatory and antimicrobial drugs are diclofenac
sodium (DFS) and oxytetracycline (OTC), especially in developing countries because they …

[图书][B] Drug-induced liver disease

N Kaplowitz, LD DeLeve - 2007 - taylorfrancis.com
Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Possible ecological risk of two pharmaceuticals diclofenac and paracetamol demonstrated on a model plant Lemna minor

M Kummerová, Š Zezulka, P Babula, J Tříska - Journal of hazardous …, 2016 - Elsevier
Lemna minor is often used in environmental risk assessment and it can be supposed that
usually evaluated parameters will be reliable even for assessing the risk of pharmaceuticals …