Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …

The tumor microenvironment (TME) is composed of various cell types embedded in an
altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Background Angiogenesis is the process of neovascularization from pre-existing
vasculature and is involved in various physiological and pathological processes. Inhibitors …

Abstract Background Pancreatic stellate cells (PSCs), a major component of the tumor
microenvironment in pancreatic cancer, play roles in cancer progression as well as drug …

The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Anemia is common in colorectal cancer (CRC) but its relationships with tumor
characteristics, systemic inflammation, and survival have not been well characterized. In this …

Cell migration and invasion is a key driving factor for providing essential cellular functions
under physiological conditions or the malignant progression of tumors following downward …

In recent years, it has become increasingly evident that cancer cells and the local
microenvironment are crucial in the development and progression of tumors. One of the …

Recent studies have reported of an association between high serum apolipoprotein A1
(APOA1) levels and favorable prognosis in several malignancies, while the significance of …