Microfluidics: Fluid physics at the nanoliter scale

TM Squires, SR Quake - Reviews of modern physics, 2005 - APS
Microfabricated integrated circuits revolutionized computation by vastly reducing the space,
labor, and time required for calculations. Microfluidic systems hold similar promise for the …

Poly (dimethylsiloxane) as a material for fabricating microfluidic devices

JC McDonald, GM Whitesides - Accounts of chemical research, 2002 - ACS Publications
This Account summarizes techniques for fabrication and applications in biomedicine of
microfluidic devices fabricated in poly (dimethylsiloxane)(PDMS). The methods and …

An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids

V Srinivasan, VK Pamula, RB Fair - Lab on a Chip, 2004 - pubs.rsc.org
Clinical diagnostics is one of the most promising applications for microfluidic lab-on-a-chip
systems, especially in a point-of-care setting. Conventional microfluidic devices are usually …

Electrowetting-based actuation of droplets for integrated microfluidics

MG Pollack, AD Shenderov, RB Fair - Lab on a Chip, 2002 - pubs.rsc.org
The serviceability of microfluidics-based instrumentation including 'lab-on-a-chip'systems
critically depends on control of fluid motion. We are reporting here an alternative approach …

Induced-charge electro-osmosis

TM Squires, MZ Bazant - Journal of Fluid Mechanics, 2004 - cambridge.org
We describe the general phenomenon of 'induced-charge electro-osmosis'(ICEO)–the
nonlinear electro-osmotic slip that occurs when an applied field acts on the ionic charge it …

Preimplantation genetic diagnosis

K Sermon, A Van Steirteghem, I Liebaers - The Lancet, 2004 - thelancet.com
Preimplantation genetic diagnosis (PGD) was introduced at the beginning of the 1990s as
an alternative to prenatal diagnosis, to prevent termination of pregnancy in couples with a …

Lab-on-a-chip for drug development

BH Weigl, RL Bardell, CR Cabrera - Advanced drug delivery reviews, 2003 - Elsevier
Significant advances have been made in the development of micro-scale technologies for
biomedical and drug discovery applications. The first generation of microfluidics-based …

Microfluidic chips for clinical and forensic analysis

E Verpoorte - Electrophoresis, 2002 - Wiley Online Library
This review gives an overview of developments in the field of microchip analysis for clinical
diagnostic and forensic applications. The approach chosen to review the literature is …

Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry

AJ Tüdős, GAJ Besselink, RBM Schasfoort - Lab on a Chip, 2001 - pubs.rsc.org
A currently emerging approach enables more widespread monitoring of health parameters
in disease prevention and biomarker monitoring. Miniaturisation provides the means for the …

Breaking symmetries in induced-charge electro-osmosis and electrophoresis

TM Squires, MZ Bazant - Journal of Fluid Mechanics, 2006 - cambridge.org
Building on our recent work on induced-charge electro-osmosis (ICEO) and electrophoresis
(ICEP), as well as the Russian literature on spherical metal colloids, we examine the rich …