The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

[HTML][HTML] Tissue engineering and cell-based therapies for fractures and bone defects

JR Perez, D Kouroupis, DJ Li, TM Best… - … in bioengineering and …, 2018 - frontiersin.org
Bone fractures and segmental bone defects are a significant source of patient morbidity and
place a staggering economic burden on the healthcare system. The annual cost of treating …

[HTML][HTML] Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration

SM Richardson, G Kalamegam, PN Pushparaj, C Matta… - Methods, 2016 - Elsevier
Musculoskeletal disorders represent a major cause of disability and morbidity globally and
result in enormous costs for health and social care systems. Development of cell-based …

[HTML][HTML] Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy

VV Maldonado, NH Patel, EE Smith, CL Barnes… - Journal of biological …, 2023 - Springer
Mesenchymal stem/stromal cells (MSCs) have been carefully examined to have tremendous
potential in regenerative medicine. With their immunomodulatory and regenerative …

[HTML][HTML] Umbilical cord-derived mesenchymal stem cells: their advantages and potential clinical utility

T Nagamura-Inoue, H He - World journal of stem cells, 2014 - ncbi.nlm.nih.gov
Human umbilical cord (UC) is a promising source of mesenchymal stem cells (MSCs). Apart
from their prominent advantages, such as a painless collection procedure and faster self …

[HTML][HTML] The role of mesenchymal stem cells in hematopoietic stem cell transplantation: prevention and treatment of graft-versus-host disease

L Zhao, S Chen, P Yang, H Cao, L Li - Stem cell research & therapy, 2019 - Springer
Background The use and effectiveness of hematopoietic stem cell transplantation (HSCT)
are limited by lethal complications, ie, acute and chronic graft-versus-host disease (aGVHD …

The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton's jelly of the human umbilical cord

A Bongso, CY Fong - Stem Cell Reviews and Reports, 2013 - Springer
Mesenchymal stem cells (MSCs) from bone marrow, adult organs and fetuses face the
disadvantages of invasive isolation, limited cell numbers and ethical constraints while …

Isolation and characterization of mesenchymal stem cells from human umbilical cord blood: reevaluation of critical factors for successful isolation and high ability to …

X Zhang, M Hirai, S Cantero… - Journal of cellular …, 2011 - Wiley Online Library
Human umbilical cord blood (CB) is a potential source for mesenchymal stem cells (MSC)
capable of forming specific tissues, for example, bone, cartilage, or muscle. However …

[HTML][HTML] Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410

L Dong, Y Pu, L Zhang, Q Qi, L Xu, W Li, C Wei… - Cell death & …, 2018 - nature.com
Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor
growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the …

Wharton's Jelly stem cells: future clinical applications

RR Taghizadeh, KJ Cetrulo, CL Cetrulo - Placenta, 2011 - Elsevier
This review focuses on the therapeutic potential of stem cells harvested from the Wharton's
Jelly of the human umbilical cord. Recently, investigators have found that a potent stem cell …