C. Mechanisms underlying modulation of parathyroid hormone secretion in response to
changes in extracellular calcium concentration persisting for hours to several days …

Hyperparathyroidism occurs in most patients during the progression of chronic kidney
disease (CKD) and one of its initiating events, reduced serum levels of 1, 25 …

The resistance of parathyroid cells to 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) in uremic
hyperparathyroidism is thought to be caused, in part, by a 1, 25 (OH) 2D3 receptor (VDR) …

Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism. Background
Management of secondary hyperparathyroidism has included the use of active vitamin D or …

The calcium-sensing receptor (CASR), expressed in parathyroid chief cells, thyroid C-cells,
and cells of the kidney tubule, is essential for maintenance of calcium homeostasis. Here we …

Control of phosphorus accumulation in chronic renal insufficiency is crucial to the prevention
of secondary hyperparathyroidism and metastatic calcification. In early renal failure, calcitriol …

Development of adynamic bone in patients with secondary hyperparathyroidism after
intermittent calcitriol therapy. Intermittent calcitriol therapy is commonly used to treat …

Morphological changes in the parathyroid glands evidently occur early during renal failure.
Histopathological investigations have suggested that parathyroid cells initially increase …

Context: Controversy persists over: 1) how best to restore low serum 25-hydroxyvitamin D
(25D) levels (vitamin D2 [D2] vs vitamin D3 [D3]); 2) how best to define vitamin D status (total …

Treatment with vitamin D sterols can lower plasma parathyroid hormone (PTH) in many
patients with secondary hyperparathyroidism due to end-stage renal disease, but …