Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Background Histone lactylation has been recently described as a novel histone post-
translational modification linking cellular metabolism to epigenetic regulation. Results Given …

Despite their importance in tissue homeostasis and renewal, human pituitary stem cells
(PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and …

Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

Introduction: One of the key factors that may influence the therapeutic potential of
mesenchymal stem/stromal cells (MSCs) is their metabolism. The switch between …

The impaired differentiation ability of resident cells and disordered immune
microenvironment in periodontitis pose a huge challenge for bone regeneration. Herein, we …

Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that
nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly …

Energy metabolism plays an important role in cell and tissue ability to effectively function,
maintain homeostasis, and perform repair. Yet, the role of energy metabolism in skeletal …

Aging is a natural process that determined by a functional decline in cells and tissues as
organisms are growing old, resulting in an increase at risk of disease and death. To this end …