Visceral leishmaniasis (VL) is caused by Leishmania donovani and Leishmania infantum.
The burden of VL is concentrated in tropical and subtropical areas; however, HIV infection …

Soon after the identification of Leishmania parasite as a causative agent, the pentavalent
antimony compounds have been the mainstay to treat all forms of leishmaniasis. Due to …

The diterpenoid alkaloids are a family of extremely important natural products that have long
been a research hotspot due to their myriad of intricate structures and diverse biological …

Despite advancements in the areas of omics and chemoinformatics, potent novel
biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The …

Several Ranunculaceae species are used in folk medicine to eliminate pathologies
associated with oxidative stress as well as parasitic infections; however, a number of studies …

Radix aconiti lateralis (Fuzi) is widely used in China as a traditional Chinese medicine for
the treatment of asthenia, pain and inflammation. However, its toxic alkaloids often lead to …

Abstract Treatment against visceral leishmaniasis (VL) presents problems, mainly related to
drug toxicity, high cost and/or by emergence of resistant strains. In the present study, two …

A phytochemical study of the root barks of Aconitum sinchiangense WT Wang, a traditional
Chinese herb medicine, led to the isolation of 15 diterpenoid alkaloids, including one new …

The genus Aconitum belongs to the family Ranunculaceae, is endowed with more than 350
species on the earth. Medicinally important aconitine type of diterpenoid alkaloids are the …

Abstract The genus Aconitum (family—Ranunculaceae) accounts for approximately 400
species worldwide, of which some are considered medicinally very relevant. Many species …