Fluorogenic probes for disease-relevant enzymes

J Zhang, X Chai, XP He, HJ Kim, J Yoon… - Chemical Society …, 2019 - pubs.rsc.org
Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

[HTML][HTML] Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes

J Ramos-Soriano, M Ghirardello… - Chemical Society Reviews, 2022 - pubs.rsc.org
Cell surface carbohydrates mediate a wide range of carbohydrate–protein interactions key
to healthy and disease mechanisms. Many of such interactions are multivalent in nature and …

[HTML][HTML] Multiplexed photoluminescent sensors: towards improved disease diagnostics

XP He, XL Hu, TD James, J Yoon, H Tian - Chemical Society Reviews, 2017 - pubs.rsc.org
The ability to simultaneously monitor multiple analytes in, for example, a single microplate
well, is important for both basic research and clinical applications. In particular, for disease …

[HTML][HTML] Carbohydrate CuAAC click chemistry for therapy and diagnosis

XP He, YL Zeng, Y Zang, J Li, RA Field… - Carbohydrate Research, 2016 - Elsevier
Carbohydrates are important as signaling molecules and for cellular recognition events,
therefore offering scope for the development of carbohydrate-mimetic diagnostics and drug …

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

XL Hu, N Kwon, KC Yan, AC Sedgwick… - Advanced Functional …, 2020 - Wiley Online Library
Human beings are “machines” that use endogenously produced biomolecules as
“components” in signaling and for the maintenance of the body. These biomolecules consist …

Fluorescent glycoconjugates and their applications

B Thomas, KC Yan, XL Hu… - Chemical Society …, 2020 - pubs.rsc.org
Glycoconjugates and their applications as lectin ligands in biology have been thoroughly
investigated in the past decades. Meanwhile, the intrinsic properties of such multivalent …

Physically-triggered nanosystems based on two-dimensional materials for cancer theranostics

DK Ji, C Ménard-Moyon, A Bianco - Advanced Drug Delivery Reviews, 2019 - Elsevier
There is an increasing demand to develop effective methods for treating malignant diseases
to improve healthcare in our society. Stimuli-responsive nanosystems, which can respond to …

Photoluminescence architectures for disease diagnosis: from graphene to thin‐layer transition metal dichalcogenides and oxides

XP He, H Tian - Small, 2016 - Wiley Online Library
Ever since the discovery of graphene, increasing efforts have been devoted to the use of this
stellar material as well as the development of other graphene‐like materials such as thin …

[HTML][HTML] Lightening up membrane receptors with fluorescent molecular probes and supramolecular materials

XP He, H Tian - Chem, 2018 - cell.com
Membrane receptors, among other membrane proteins that universally exist on the cell
surface, are a class of important macromolecules responsible for cell-signaling processes …

[HTML][HTML] Fluorescent glycoprobes: a sweet addition for improved sensing

XP He, Y Zang, TD James, J Li, GR Chen… - Chemical …, 2017 - pubs.rsc.org
The development of small-molecule fluorescent probes for the detection of ions and
biomacromolecules and for cellular and in vivo imaging has been a very active research …