Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal
transducers. They regulate essential cellular processes like proliferation, apoptosis …

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …

Integrated sequencing strategies have provided a broader understanding of the genomic
landscape and molecular classifications of multiple cancer types and have identified various …

For about four decades, platelet-derived growth factors (PDGF) and their receptors have
been the subject of intense research, revealing their roles in embryo development and …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Searching for targets that allow pharmacological inhibition of cell proliferation in over-
proliferative states, such as cancer, leads us to finely understand the complex mechanisms …

Sarcoma subtype classification is currently mainly based upon histopathological
morphology. Molecular analyses have emerged as an efficient addition to the diagnostic …

Glioblastoma (GBM) is the most malignant primary brain tumor without effective therapies.
Since bevacizumab was FDA approved for targeting vascular endothelial growth factor …