The interactions between cancer cells and their micro-and macroenvironment create a
context that promotes tumour growth and protects it from immune attack. The functional …

Gap junctions are plasma membrane spatial microdomains constructed of assemblies of
channel proteins called connexins in vertebrates and innexins in invertebrates. The …

Gap junctions allow the exchange of ions, second messengers, and small metabolites
between adjacent cells and are formed by two unrelated protein families, the pannexins and …

Epithelia separate tissue spaces by regulating the passage of ions, solutes, and water
through both the transcellular and paracellular pathways. Paracellular permeability is …

Connexin channels are known to be permeable to a variety of cytoplasmic molecules. The
first observation of second messenger junctional permeability, made∼ 30 years ago …

Gap junctions consist of intercellular channels dedicated to providing a direct pathway for
ionic and biochemical communication between contacting cells. After an initial burst of …

Gap junctions establish direct pathways for cell-to-cell communication through the assembly
of twelve connexin subunits that form intercellular channels connecting neighbouring cells …

Over the last two decades, the view of gap junction (GJ) channel gating has changed from
one with GJs having a single transjunctional voltage-sensitive (Vj-sensitive) gating …

The prefrontal cortex (PFC) is implicated in a variety of cognitive and executive functions and
is composed of several distinct networks, including anterior cingulate cortex (ACC), medial …

Gap junctions mediate the transfer of small cytoplasmic molecules between adjacent cells. A
family of gap junction proteins exist that form channels with unique properties, and differ in …