UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental carcinogens and
metabolized by a variety of xenobiotic-metabolizing enzymes such as cytochrome P450 …

Background Racial disparities in cancer outcomes have been observed in several
malignancies. However, it is unclear if survival differences persist after adjusting for clinical …

ABSTRACT UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key
proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse …

Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

Hyperbilirubinemia is an important clinical sign that often indicates severe hepatobiliary
disease of different etiologies. Inherited non-haemolytichyperbilirubinemic conditions …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with important
roles in metabolic adaptation, normal physiology and dioxin toxicology. Metabolic …

This review focuses on genes other than the high penetrance genes BRCA1 and BRCA2
that are involved in breast cancer susceptibility. The goal of this review is the discovery of …

This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …

Bilirubin, the principal bile pigment, is the end product of heme catabolism. For many years,
bilirubin was thought to have no physiological function other than that of a waste product of …