Micro‐nanocarriers based drug delivery technology for blood‐brain barrier crossing and brain tumor targeting therapy

L Wang, Y Shi, J Jiang, C Li, H Zhang, X Zhang… - Small, 2022 - Wiley Online Library
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …

Engineered living materials for advanced diseases therapy

X Dong, W Wu, P Pan, XZ Zhang - Advanced Materials, 2023 - Wiley Online Library
Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …

[HTML][HTML] Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy

C Chang, W Guo, X Yu, C Guo, N Zhou, X Guo… - Materials Today Bio, 2023 - Elsevier
Bacteriophages (phages) are nanostructured viruses with highly selective antibacterial
properties that have gained attention beyond eliminating bacteria. Specifically, M13 phages …

[HTML][HTML] M13 phage: a versatile building block for a highly specific analysis platform

R Wang, HD Li, Y Cao, ZY Wang, T Yang… - Analytical and …, 2023 - Springer
Viruses are changing the biosensing and biomedicine landscape due to their multivalency,
orthogonal reactivities, and responsiveness to genetic modifications. As the most extensively …

Unraveling the potential of M13 phages in biomedicine: Advancing drug nanodelivery and gene therapy

M Fadaie, H Dianat-Moghadam, E Ghafouri… - Environmental …, 2023 - Elsevier
M13 phages possessing filamentous phage genomes offer the benefits of selective display
of molecular moieties and delivery of therapeutic agent payloads with a tolerable safety …

Improvement of gene delivery by minimal bacteriophage particles

CY Kao, YC Pan, YH Hsiao, SK Lim, TW Cheng… - ACS …, 2023 - ACS Publications
Direct delivery of therapeutic genes is a promising approach for treating cancers and other
diseases. The current human viral vectors, however, suffer from several drawbacks …

Phage display based biosensing: Recent advances and challenges

M Wang, S Pang, H Zhang, Z Yang, A Liu - TrAC Trends in Analytical …, 2024 - Elsevier
Phage display enables to screen probes such as peptide, antibody and nanobody with high
specificity and affinity to the target, providing excellent probes for various analytical or …

[HTML][HTML] Phage-based delivery systems: Engineering, applications, and challenges in nanomedicines

H Wang, Y Yang, Y Xu, Y Chen, W Zhang, T Liu… - Journal of …, 2024 - Springer
Bacteriophages (phages) represent a unique category of viruses with a remarkable ability to
selectively infect host bacteria, characterized by their assembly from proteins and nucleic …

[HTML][HTML] Harnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subtyping

HD Li, YQ Chen, Y Li, X Wei, SY Wang, Y Cao… - Nature …, 2024 - nature.com
The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is
still challenging due to the lack of a capturing surface with strong target-binding affinity and …

[HTML][HTML] Strategies increasing the effectiveness of temozolomide at various levels of anti-GBL therapy

A Krajcer, E Grzywna… - Biomedicine & …, 2023 - Elsevier
Glioblastoma (GBL) is the most common (60–70% of primary brain tumours) and the most
malignant of the glial tumours. Although current therapies remain palliative, they have been …