This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

The organ of Corti in the mammalian inner ear is comprised of mechanosensory hair cells
(HCs) and nonsensory supporting cells (SCs), both of which are believed to be terminally …

Histological alterations often constitute a fingerprint of toxicity and diseases. The extent to
which these alterations are cause or consequence of compromised organ function, and the …

The nuclear receptors CAR (constitutive androstane receptor) and possibly PXR (pregnane
X receptor) mediate the hepatic effects of phenobarbital (PB) and similar-acting compounds …

BACKGROUND & AIMS: Wnt/β-catenin signaling is important in liver physiology. Moreover,
β-catenin is also pivotal in adherens junctions (AJ). Here, we investigate hepatocyte-specific …

The antiepileptic drug phenobarbital (PB) is a potent tumor promoter in mouse liver, where it
stimulates the selective outgrowth of tumor populations harboring activating mutations in …

During liver development and regeneration, hepatocytes undergo rapid cell division and
face an increased risk of DNA damage associated with active DNA replication. The …

Genes involved in detoxification of foreign compounds exhibit complex spatiotemporal
expression patterns in liver. Cytochrome P450 1A1 (CYP1A1), for example, is restricted to …

Aberrant signaling through the Wnt/β-catenin pathway is a critical determinant in human and
rodent liver carcinogenesis and generally accepted to be a potent driver of proliferation …

Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and
fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as …