Substantial changes in the 2021 WHO Classification of Tumors of the Pleura and
Pericardium since the 2015 WHO Classification include the following:(1) pleural and …

The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation,
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …

Introduction Highly aggressive thoracic neoplasms characterized by SMARCA4 (BRG1)
deficiency and undifferentiated round cell or rhabdoid morphology have been recently …

Epigenetic regulation is critical to physiological control of development, cell fate, cell
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …

The molecular pathogenesis of poorly differentiated sinonasal carcinoma received
significant attention in recent years. As a consequence, several unclassified carcinomas in …

Germline inactivating mutations in SMARCA4 (SWI/SNF-related, matrix-associated, actin-
dependent regulator of chromatin, subfamily A, member 4) gene encoding for BRG1 …

SMARCA4‐deficient thoracic sarcoma (SMARCA4‐DTS) is a new clinical entity
characterized by SMARCA4 inactivation and has a dismal prognosis because of rapid …

Malignant rhabdoid tumors (MRTs) are a subtype of undifferentiated soft tissue sarcoma
(STS) characterized by bi-allelic loss of function mutation in SMARCB1, a core subunit of the …

Background Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) are
aggressive neoplasms. Data linking BAF alterations with tumor microenvironment (TME) and …

Undifferentiated carcinoma of the gastrointestinal tract has variable rhabdoid features.
Expression of switch/sucrose nonfermenting (SWI/SNF) complex subunits is reportedly lost …