Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural
spirooxindole-containing compounds have been identified as bio-promising agents …

Alkaloids found in multiple species, known as 'driver species', are more likely to be included
in early-stage drug development due to their high biodiversity compared to rare alkaloids …

Currently, limited therapeutic options are available for severe acute respiratory syndrome
coronavirus‐2 (SARS‐CoV‐2). We have developed a set of pyrazine‐based small …

A series of curcumin bis-conjugates 3a-q, 5a-k and 6a-k were synthesized in good yields
utilizing an optimized reaction condition. We explored the effect of different amino acids and …

The broad spectrum of curcumin's beneficial properties has encouraged medicinal
researchers to investigate its therapeutic efficacy against diverse diseases. The clinical …

Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …

Benzotriazole is an important heterocyclic compound in pharmaceutical and material
chemistry, its derivatives have found wide applications for synthetic organic chemistry. N …

Several rationally designed isoniazid (INH), pyrazinamide (PZA) and ciprofloxacin (CPF)
derivatives were conveniently synthesized and evaluated in vitro against H37Rv …

In the present work, four Ibuprofen drug hybrids (1–4) were designed by modifying free
amino groups of 4-aminoantipyrine, sulfamethoxazole, pyrazinamide, and isoniazid …

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb), each
year causing millions of deaths. In this article, we present the synthesis and biological …