Hypoxia is an important feature of the tumor microenvironment, and is closely associated
with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these …

Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …

Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Mitochondria-specific photosensitizer accumulation is highly recommended for
photodynamic therapy and mitochondrial DNA (mtDNA) oxidative damage-based innate …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Abstract Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …

Cellular homeostasis plays a critical role in how an organism will develop and age.
Disruption of this fragile equilibrium is often associated with health degradation and …

Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …

Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …

Photodynamic therapy (PDT) is a promising treatment strategy where activation of
photosensitizer drugs with specific wavelengths of light results in energy transfer cascades …