Twenty-five-year research progress in hookworm excretory/secretory products

AMI Abuzeid, X Zhou, Y Huang, G Li - Parasites & vectors, 2020 - Springer
Hookworm infection is a major public health problem that threatens about 500 million people
throughout tropical areas of the world. Adult hookworms survive for many years in the host …

Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants

RHP Wilbers, R Schneiter, MHM Holterman… - PLoS …, 2018 - journals.plos.org
Despite causing considerable damage to host tissue at the onset of parasitism, invasive
helminths establish remarkably persistent infections in both animals and plants. Secretions …

Characterization of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host–parasite communication

RM Eichenberger, MH Talukder, MA Field… - Journal of …, 2018 - Taylor & Francis
Whipworms are parasitic nematodes that live in the gut of more than 500 million people
worldwide. Owing to the difficulty in obtaining parasite material, the mouse whipworm …

IL-33: a central cytokine in helminth infections

HJ McSorley, DJ Smyth - Seminars in Immunology, 2021 - Elsevier
IL-33 is an alarmin cytokine which has been implicated in allergy, fibrosis, inflammation,
tumorigenesis, metabolism, and homeostasis. However, amongst its strongest roles are in …

Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms

J Logan, MS Pearson, SS Manda, YJ Choi… - PLoS neglected …, 2020 - journals.plos.org
The human hookworm Necator americanus infects more than 400 million people worldwide,
contributing substantially to the poverty in these regions. Adult stage N. americanus live in …

Of dogs and hookworms: man's best friend and his parasites as a model for translational biomedical research

C Shepherd, P Wangchuk, A Loukas - Parasites & vectors, 2018 - Springer
We present evidence that the dog hookworm (Ancylostoma caninum) is underutilised in the
study of host-parasite interactions, particularly as a proxy for the human-hookworm …

Mining nematode protein secretomes to explain lifestyle and host specificity

L Tritten, C Ballesteros, R Beech… - PLoS Neglected …, 2021 - journals.plos.org
Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals
and plants. Despite great differences in their life cycles, host preference and transmission …

Helminth-induced regulatory T cells and suppression of allergic responses

J Logan, S Navarro, A Loukas, P Giacomin - Current opinion in immunology, 2018 - Elsevier
Highlights•Infections with parasitic helminths (worms) may protect against development of
inflammatory and allergic diseases.•Helminths infections promote regulatory immune cell …

In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination

J Sotillo, MS Pearson, L Becker… - PLoS neglected …, 2019 - journals.plos.org
Background Schistosomiasis is a neglected disease affecting hundreds of millions
worldwide. Of the three main species affecting humans, Schistosoma haematobium is the …

The Angiostrongylus vasorum Excretory/Secretory and Surface Proteome Contains Putative Modulators of the Host Coagulation

N Germitsch, T Kockmann, LM Asmis… - Frontiers in Cellular …, 2021 - frontiersin.org
Angiostrongylus vasorum is a cardiopulmonary nematode of canids and is, among others,
associated with bleeding disorders in dogs. The pathogenesis of such coagulopathies …