The endoplasmic reticulum is primarily responsible for protein folding and maturation.
However, the organelle is subject to varied stress conditions from time to time, which lead to …

The integrated stress response (ISR) is an adaptational signaling pathway induced in
response to different stimuli, such as accumulation of unfolded and misfolded proteins …

Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …

Calcium overload and ROS overproduction, two major triggers of acute kidney injury (AKI),
are self‐amplifying and mutually reinforcing, forming a complicated cascading feedback …

A number of new cell death processes have been discovered in recent years, including
ferroptosis, which is characterized by the accumulation of lipid peroxidation products derived …

Background Endoplasmic reticulum (ER) stress is involved in the progression of Alzheimer's
disease (AD). Verbascoside (VB), an active phenylethanoid glycoside that was first isolated …

ABSTRACT DNA damage-inducible transcript 3 (DDIT3) plays important roles in
endoplasmic reticulum (ER) stress-induced apoptosis and autophagy, but its role in innate …

The endoplasmic reticulum (ER) comprises a network of tubules and vesicles that
constitutes the largest organelle of the eukaryotic cell. Being the location where most …

The endoplasmic reticulum (ER) plays a vital function in maintaining cellular homeostasis.
Endoplasmic reticulum stress (ERS) can trigger various modes of cell death by activating the …

Background Endoplasmic reticulum stress (ERS)-mediated myocardial inflammation and
apoptosis plays an important role in myocardial ischemia/reperfusion (I/R) injury …