Modern health care has brought our society innumerable benefits but has also introduced
the experience of pain very early in life. For example, it is now routine care for newborns to …

Pain experienced during neonatal intensive care management can influence
neurodevelopmental outcome and the somatosensory and/or emotional components of pain …

Paediatric pain and its assessment and management are challenging for medical
professionals, especially in an urgent care environment. Patients in a paediatric emergency …

Ethnopharmacological relevance Rheumatoid arthritis (RA) is a chronic autoimmune
disease characterized by synovial inflammation and arthritic pain. Sinomenine (SIN) …

A peripheral injury drives neuroimmune interactions at the level of the injury and throughout
the neuraxis. Understanding these systems will be beneficial in the pursuit to target …

The nociceptive network, responsible for transmission of nociceptive signals that generate
the pain experience, is not fully developed at birth. Descending serotonergic modulation of …

Preterm infants often spend a significant amount of time in the neonatal intensive care unit
(NICU) where they are exposed to many stressors including pain and reduced maternal …

Early life pain (ELP) experience alters adult pain behavior and increases injury-induced
pain hypersensitivity, but the effect of ELP on adult functional brain connectivity is not known …

Forty-five years ago, Patrick Wall published his John J Bonica lecture “On the relation of
injury to pain.” 90 In this lecture, he argued that pain is better classified as an awareness of a …

Preterm infants in neonatal intensive care units are inevitably subjected to numerous painful
procedures. However, little is known about the consequences of early pain experience on …