The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions …

There is a growing consensus that the various forms of cell death (necrosis, apoptosis and
autophagy) are not separated by strict boundaries, but rather share molecular effectors and …

Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural
feature, providing the physical basis for intercommunication during Ca2+ signalling; yet, the …

The recognition events that mediate adaptive cellular immunity and regulate antibody
responses depend on intercellular contacts between T cells and antigen-presenting cells …

The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane
mediates metabolic flow, Ca2+, and cell death signaling between the endoplasmic reticulum …

Background Although the insulin-producing pancreatic β-cells are quite capable of adapting
to both acute and chronic changes in metabolic demand, persistently high demand for …

Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics
for undergraduate or graduate students. It maps the huge and complex landscape of cell …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …

Electron microscopy played a key role in establishing cell biology as a discipline, by
producing fundamental insights into cellular organization and ultrastructure. Many seminal …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …