Copanlisib population pharmacokinetics from phase I–III studies and exposure–response relationships in combination with rituximab
PN Morcos, J Moss, R Austin… - CPT …, 2023 - Wiley Online Library
Copanlisib dose selection was established under the maximum tolerated dose paradigm,
and no dedicated dose‐finding studies have investigated copanlisib dose selection when …
and no dedicated dose‐finding studies have investigated copanlisib dose selection when …
Predictive performance of physiology‐based pharmacokinetic dose estimates for pediatric trials: evaluation with 10 Bayer small‐molecule compounds in children
I Ince, A Dallmann, S Frechen… - The Journal of …, 2021 - Wiley Online Library
Abstract Development and guidance of dosing schemes in children have been supported by
physiology‐based pharmacokinetic (PBPK) modeling for many years. PBPK models are built …
physiology‐based pharmacokinetic (PBPK) modeling for many years. PBPK models are built …