[HTML][HTML] Cell biology of the NCL proteins: what they do and don't do
J Cárcel-Trullols, AD Kovács, DA Pearce - Biochimica et Biophysica Acta …, 2015 - Elsevier
The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …
Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases
Age-associated neurodegenerative disorders such as Alzheimer's disease are a major
public health challenge, due to the demographic increase in the proportion of older …
public health challenge, due to the demographic increase in the proportion of older …
DNAJ Proteins in neurodegeneration: essential and protective factors
C Zarouchlioti, DA Parfitt, W Li… - … of the Royal …, 2018 - royalsocietypublishing.org
Maintenance of protein homeostasis is vitally important in post-mitotic cells, particularly
neurons. Neurodegenerative diseases such as polyglutamine expansion disorders—like …
neurons. Neurodegenerative diseases such as polyglutamine expansion disorders—like …
Polyphenols as caloric-restriction mimetics and autophagy inducers in aging research
It has been thought that caloric restriction favors longevity and healthy aging where
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …
Metabolic effects of resveratrol: addressing the controversies
JL Bitterman, JH Chung - Cellular and Molecular Life Sciences, 2015 - Springer
Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has
received a great deal of attention for its diverse array of healthful effects. Beneficial effects of …
received a great deal of attention for its diverse array of healthful effects. Beneficial effects of …
Phenolic Compounds Reduce the Fat Content in Caenorhabditis elegans by Affecting Lipogenesis, Lipolysis, and Different Stress Responses
P Aranaz, D Navarro-Herrera, M Zabala… - Pharmaceuticals, 2020 - mdpi.com
Supplementation with bioactive compounds capable of regulating energy homeostasis is a
promising strategy to manage obesity. Here, we have screened the ability of different …
promising strategy to manage obesity. Here, we have screened the ability of different …
[HTML][HTML] Cysteine string protein (CSP) and its role in preventing neurodegeneration
RD Burgoyne, A Morgan - Seminars in cell & developmental biology, 2015 - Elsevier
Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 family of co-chaperones that
localises to neuronal synaptic vesicles. Its name derives from the possession of a string of …
localises to neuronal synaptic vesicles. Its name derives from the possession of a string of …
Neurons export extracellular vesicles enriched in cysteine string protein and misfolded protein cargo
J Deng, C Koutras, J Donnelier, M Alshehri… - Scientific reports, 2017 - nature.com
The fidelity of synaptic transmission depends on the integrity of the protein machinery at the
synapse. Unfolded synaptic proteins undergo refolding or degradation in order to maintain …
synapse. Unfolded synaptic proteins undergo refolding or degradation in order to maintain …
Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance
N Wang, B Zhu, MA Allnutt… - Proceedings of the …, 2024 - National Acad Sciences
Synapse maintenance is essential for generating functional circuitry, and decrement in this
process is a hallmark of neurodegenerative disease. Yet, little is known about synapse …
process is a hallmark of neurodegenerative disease. Yet, little is known about synapse …
Extracellular chaperone networks and the export of J-domain proteins
JEA Braun - Journal of Biological Chemistry, 2023 - ASBMB
An extracellular network of molecular chaperones protects a diverse array of proteins that
reside in or pass through extracellular spaces. Proteins in the extracellular milieu face …
reside in or pass through extracellular spaces. Proteins in the extracellular milieu face …