[HTML][HTML] Cell biology of the NCL proteins: what they do and don't do

J Cárcel-Trullols, AD Kovács, DA Pearce - Biochimica et Biophysica Acta …, 2015 - Elsevier
The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

X Chen, JW Barclay, RD Burgoyne, A Morgan - Chemistry Central Journal, 2015 - Springer
Age-associated neurodegenerative disorders such as Alzheimer's disease are a major
public health challenge, due to the demographic increase in the proportion of older …

DNAJ Proteins in neurodegeneration: essential and protective factors

C Zarouchlioti, DA Parfitt, W Li… - … of the Royal …, 2018 - royalsocietypublishing.org
Maintenance of protein homeostasis is vitally important in post-mitotic cells, particularly
neurons. Neurodegenerative diseases such as polyglutamine expansion disorders—like …

Polyphenols as caloric-restriction mimetics and autophagy inducers in aging research

A Yessenkyzy, T Saliev, M Zhanaliyeva, AR Masoud… - Nutrients, 2020 - mdpi.com
It has been thought that caloric restriction favors longevity and healthy aging where
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …

Metabolic effects of resveratrol: addressing the controversies

JL Bitterman, JH Chung - Cellular and Molecular Life Sciences, 2015 - Springer
Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has
received a great deal of attention for its diverse array of healthful effects. Beneficial effects of …

Phenolic Compounds Reduce the Fat Content in Caenorhabditis elegans by Affecting Lipogenesis, Lipolysis, and Different Stress Responses

P Aranaz, D Navarro-Herrera, M Zabala… - Pharmaceuticals, 2020 - mdpi.com
Supplementation with bioactive compounds capable of regulating energy homeostasis is a
promising strategy to manage obesity. Here, we have screened the ability of different …

[HTML][HTML] Cysteine string protein (CSP) and its role in preventing neurodegeneration

RD Burgoyne, A Morgan - Seminars in cell & developmental biology, 2015 - Elsevier
Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 family of co-chaperones that
localises to neuronal synaptic vesicles. Its name derives from the possession of a string of …

Neurons export extracellular vesicles enriched in cysteine string protein and misfolded protein cargo

J Deng, C Koutras, J Donnelier, M Alshehri… - Scientific reports, 2017 - nature.com
The fidelity of synaptic transmission depends on the integrity of the protein machinery at the
synapse. Unfolded synaptic proteins undergo refolding or degradation in order to maintain …

Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance

N Wang, B Zhu, MA Allnutt… - Proceedings of the …, 2024 - National Acad Sciences
Synapse maintenance is essential for generating functional circuitry, and decrement in this
process is a hallmark of neurodegenerative disease. Yet, little is known about synapse …

Extracellular chaperone networks and the export of J-domain proteins

JEA Braun - Journal of Biological Chemistry, 2023 - ASBMB
An extracellular network of molecular chaperones protects a diverse array of proteins that
reside in or pass through extracellular spaces. Proteins in the extracellular milieu face …