The mechanisms and roles of selective autophagy in mammals

JNS Vargas, M Hamasaki, T Kawabata… - … reviews Molecular cell …, 2023 - nature.com
Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Autophagy genes in biology and disease

H Yamamoto, S Zhang, N Mizushima - Nature Reviews Genetics, 2023 - nature.com
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Mechanisms of selective autophagy

T Lamark, T Johansen - Annual review of cell and …, 2021 - annualreviews.org
Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

Autophagy-dependent ferroptosis: machinery and regulation

J Liu, F Kuang, G Kroemer, DJ Klionsky, R Kang… - Cell chemical …, 2020 - cell.com
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …

[HTML][HTML] Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors

T Johansen, T Lamark - Journal of molecular biology, 2020 - Elsevier
Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

Autophagy-independent functions of the autophagy machinery

L Galluzzi, DR Green - Cell, 2019 - cell.com
Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism
that culminates with the lysosomal degradation of superfluous or potentially dangerous …

ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum

F Reggiori, M Molinari - Physiological reviews, 2022 - journals.physiology.org
ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

[HTML][HTML] Lysosomal microautophagy: an emerging dimension in mammalian autophagy

Y Kuchitsu, T Taguchi - Trends in Cell Biology, 2024 - cell.com
Autophagy is a self-catabolic process through which cellular components are delivered to
lysosomes for degradation. There are three types of autophagy, ie, macroautophagy …

ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4

H Wu, Q Liu, X Shan, W Gao, Q Chen - Autophagy, 2023 - Taylor & Francis
Ferroptosis is a newly characterized form of programmed cell death, which is driven by the
lethal accumulation of lipid peroxides catalyzed by the intracellular bioactive iron. Targeted …

Diverse cellular roles of autophagy

H Morishita, N Mizushima - Annual review of cell and …, 2019 - annualreviews.org
Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic
materials to lysosomes via autophagosomes. Recent advances have enabled identification …