DNA vaccines against COVID-19: Perspectives and challenges
MM Silveira, GMSG Moreira, M Mendonça - Life sciences, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known
as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated …
as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated …
Immunoinformatics and vaccine development: an overview
AN Oli, WO Obialor, MO Ifeanyichukwu… - ImmunoTargets and …, 2020 - Taylor & Francis
The use of vaccines have resulted in a remarkable improvement in global health. It has
saved several lives, reduced treatment costs and raised the quality of animal and human …
saved several lives, reduced treatment costs and raised the quality of animal and human …
Reverse vaccinology: developing vaccines in the era of genomics
A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
Designing a multi-epitope vaccine candidate to combat MERS-CoV by employing an immunoinformatics approach
Currently, no approved vaccine is available against the Middle East respiratory syndrome
coronavirus (MERS-CoV), which causes severe respiratory disease. The spike glycoprotein …
coronavirus (MERS-CoV), which causes severe respiratory disease. The spike glycoprotein …
TepiTool: a pipeline for computational prediction of T cell epitope candidates
Computational prediction of T cell epitope candidates is currently being used in several
applications including vaccine discovery studies, development of diagnostics, and removal …
applications including vaccine discovery studies, development of diagnostics, and removal …
Designing a multi-epitope based vaccine to combat Kaposi Sarcoma utilizing immunoinformatics approach
V Chauhan, T Rungta, K Goyal, MP Singh - Scientific reports, 2019 - nature.com
Kaposi's sarcoma-associated herpesvirus (KSHV) responsible for causing Kaposi sarcoma
(KS), an opportunistic angioproliferative neoplasm is emerging rapidly. Despite this there is …
(KS), an opportunistic angioproliferative neoplasm is emerging rapidly. Despite this there is …
HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity
Prediction of HLA binding affinity is widely used to identify candidate T cell epitopes, and an
affinity of 500 nM is routinely used as a threshold for peptide selection. However, the fraction …
affinity of 500 nM is routinely used as a threshold for peptide selection. However, the fraction …
Better epitope discovery, precision immune engineering, and accelerated vaccine design using immunoinformatics tools
AS De Groot, L Moise, F Terry, AH Gutierrez… - Frontiers in …, 2020 - frontiersin.org
Computational vaccinology includes epitope mapping, antigen selection, and immunogen
design using computational tools. Tools that facilitate the in silico prediction of immune …
design using computational tools. Tools that facilitate the in silico prediction of immune …
Emerging vaccine informatics
Vaccine informatics is an emerging research area that focuses on development and
applications of bioinformatics methods that can be used to facilitate every aspect of the …
applications of bioinformatics methods that can be used to facilitate every aspect of the …
Designing a novel mRNA vaccine against SARS-CoV-2: An immunoinformatics approach
SARS-CoV-2 is the deadly virus behind COVID-19, the disease that went on to ravage the
world and caused the biggest pandemic 21st century has witnessed so far. On the face of …
world and caused the biggest pandemic 21st century has witnessed so far. On the face of …