B-type lamins are fundamental components of the nuclear lamina, a complex structure that
acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most …

The rapid pace of disease gene discovery has resulted in tremendous advances in the field
of epilepsy genetics. Clinical testing with comprehensive gene panels, exomes, and …

Since the identification of the first disease causing mutation in the gene coding for emerin, a
transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants …

Purpose Lamins are the major component of nuclear lamina, maintaining structural integrity
of the nucleus. Lamin A/C variants are well established to cause a spectrum of disorders …

The nucleus is typically depicted as a sphere encircled by a smooth surface of nuclear
envelope. For most cell types, this depiction is accurate. In other cell types and in some …

Epilepsy is a common, serious neurological disorder worldwide. Although this disease can
be successfully treated in most cases, not all patients respond favorably to medical …

Aging is characterized by a progressive loss of tissue function and an increased
susceptibility to injury and disease. Many age-associated pathologies manifest an …

The nuclear lamins are important members of the intermediate filament (IF) family of
proteins, involved in structural support and regulation of the nuclear lamina. Different …

Aging is characterized by the gradual loss of tissue function and integrity. Activation of
inflammatory responses accelerates the deterioration of cells and tissues. Many studies …

Colorectal cancer is the second common cause of death worldwide. Lamin B2 (LMNB2) is
involved in chromatin remodeling and the rupture and reorganization of nuclear membrane …