Plasma cell-free metagenomic next-generation sequencing (cf-mNGS) is a non-invasive
method that may be able to identify thousands of pathogens through a hypothesis-free …

Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis.
Routinely used culture-dependent microbiological diagnostic techniques have low …

Microbial cell-free DNA (mcfDNA) sequencing is an emerging infectious disease diagnostic
tool which enables unbiased pathogen detection and quantification from plasma. The Karius …

Background Precision health is a burgeoning scientific discipline that aims to incorporate
individual variability in biological, behavioral, and social factors to develop personalized …

Background: Plasma metagenomic next-generation sequencing (mNGS) has the potential to
detect thousands of different organisms with a single test. There are limited data on the real …

The successful application of metagenomic next-generation sequencing (mNGS; or clinical
metagenomics) for the diagnosis of infectious diseases directly from a clinical specimen …

Sequencing of plasma microbial cell-free DNA (mcfDNA) has gained increased acceptance
as a valuable adjunct to standard-of-care testing for diagnosis of infections throughout the …

BACKGROUND Community-acquired pneumonia (CAP) is common in pediatrics. More
severe complicated CAP (cCAP) requires broad-spectrum empirical therapy. Cell-free …

Background Metagenomics is a powerful approach for the detection of unknown and novel
pathogens. Workflows based on Illumina short-read sequencing are becoming established …

Fever of unknown origin (FUO) caused by infection is a disease state characterized by
complex pathogens and remains a diagnostic dilemma. Metagenomic next-generation …