Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and
entrain each other, and thus affect host health and immune-mediated diseases. Here, we …

Conspectus Non-heme iron dioxygenases catalyze vital processes for human health related
to the biosynthesis of essential products and the biodegradation of toxic metabolites. Often …

Aminotransferases (ATs) are pyridoxal 5′-phosphate–dependent enzymes that catalyze
the transamination reactions between amino acid donor and keto acid acceptor substrates …

ABSTRACT Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity,
although the cause is unclear. Metabolites generated by gut microbes also appear to be …

Selenopeptides are promising candidates for intervening in neuroinflammation; however,
the key role of selenium (Se) in selenopeptides remains poorly understood. To address this …

Amino acids are naturally occurring and structurally diverse metabolites in biological system,
whose potentials for chemical expansion, however, have not been fully explored. Here, we …

Specific bacteria of the human microbiome influence carcinogenesis at diverse anatomical
sites. Bacterial vaginosis (BV) is the most common vaginal disorder in premenopausal …

Hundreds of metabolic enzymes work together smoothly in a cell. These enzymes are highly
specific. Nevertheless, under physiological conditions, many perform side-reactions at low …

Promiscuous enzymes often serve as the starting point for the evolution of novel functions.
Yet, the extent to which the promiscuity of an individual enzyme can be harnessed several …

SAR11 bacteria are the most abundant microorganisms in the surface ocean and have
global biogeochemical importance,–. To thrive in their competitive oligotrophic environment …