An important measure of cardiovascular health is obtained by evaluating the global
cardiovascular risk, which comprises a number of factors, including hypertension and type 2 …

Chronic diabetic foot ulcers (DFUs) are a significant complication of diabetes mellitus, often
leading to amputation, increased morbidity, and a substantial financial burden. Even with the …

Peroxisomes are ubiquitous, oxidative subcellular organelles with important functions in
cellular lipid metabolism and redox homeostasis. Loss of peroxisomal functions causes …

The NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the
oxidation of the 15 (S)-hydroxyl group of prostaglandin E2 (PGE2), converting the pro …

The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the key
decisive factor controlling the development of adipocytes. Ligand-mediated activation of …

keto-PGE 2 is one of the eicosanoids with anti-inflammatory properties. In this study, we
demonstrated that 15-keto-PGE 2 post-translationally modified the nuclear factor κ-light …

Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) are anchored at the outer leaflet
of the plasma membrane (PM) bilayer by covalent linkage to a typical glycolipid and …

A metabolic hallmark of many cancers is the increase in glucose consumption coupled to
excessive lactate production. Mindful that L-lactate originates only from pyruvate, the …

Adipose tissue has been established as an endocrine organ that plays an important role in
maintaining metabolic homeostasis. Adipose tissue releases several bioactive molecules …

Abstract Polo‐like kinase 1 (PLK1) is an important cell cycle kinase and an attractive target
for anticancer treatments. An ATP‐competitive small molecular PLK1 inhibitor, volasertib …