Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders

X Yang, B Su, X Zhang, Y Liu, H Wu… - Journal of leukocyte …, 2020 - academic.oup.com
The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …

Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection

P Corbeau, J Reynes - Blood, The Journal of the American …, 2011 - ashpublications.org
Although highly active antiretroviral therapy has enabled constant progress in reducing HIV-
1 replication, in some patients who are “aviremic” during treatment, the problem of …

Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions

JC Gaardbo, HJ Hartling, J Gerstoft… - Journal of Immunology …, 2012 - Wiley Online Library
Treatment of HIV‐infected patients with highly active antiretroviral therapy (HAART) usually
results in diminished viral replication, increasing CD4+ cell counts, a reversal of most …

Altered CD4+ T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals

M Mavigner, M Cazabat, M Dubois… - The Journal of …, 2012 - Am Soc Clin Investig
Depletion of CD4+ T cells from the gut occurs rapidly during acute HIV-1 infection. This has
been linked to systemic inflammation and disease progression as a result of translocation of …

[PDF][PDF] Failure of CD4+ T-cell recovery upon virally-effective cART: an enduring gap in the understanding of HIV+ immunological non-responders

V Bono, M Augello, C Tincati, G Marchetti - New Microbiol, 2022 - newmicrobiologica.org
A unique definition of INR is currently unavailable. Over the years, INRs have generally
been described as subjects who did not reach pre-defined CD4+ lymphocyte counts (ie 200 …

HIV-1 residual viremia correlates with persistent T-cell activation in poor immunological responders to combination antiretroviral therapy

M Mavigner, P Delobel, M Cazabat, M Dubois… - PLoS …, 2009 - journals.plos.org
Background The clinical significance and cellular sources of residual human
immunodeficiency virus type 1 (HIV-1) production despite suppressive combination …

Simian immunodeficiency virus persistence in cellular and anatomic reservoirs in antiretroviral therapy-suppressed infant rhesus macaques

M Mavigner, J Habib, C Deleage, E Rosen… - Journal of …, 2018 - Am Soc Microbiol
Worldwide, nearly two million children are infected with human immunodeficiency virus
(HIV), with breastfeeding accounting for the majority of contemporary HIV transmissions …

Discordant immune response with antiretroviral therapy in HIV-1: a systematic review of clinical outcomes

C Kelly, KM Gaskell, M Richardson, N Klein, P Garner… - PloS one, 2016 - journals.plos.org
Background A discordant immune response (DIR) is a failure to satisfactorily increase CD4
counts on ART despite successful virological control. Literature on the clinical effects of DIR …

Correlation between genotypic predictions based on V3 sequences and phenotypic determination of HIV-1 tropism

S Raymond, P Delobel, M Mavigner, M Cazabat… - Aids, 2008 - journals.lww.com
Objective: Replacing phenotypic assays with simple genotypic predictions of HIV-1
coreceptor usage would make the clinical use of CCR5 antagonists easier. Design: Paired …

[HTML][HTML] Altered phenotypic and functional characteristics of CD3+ CD56+ NKT-like cells in human gastric cancer

L Peng, F Mao, Y Zhao, T Wang, N Chen, J Zhang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract CD3+ CD56+ natural killer T (NKT)-like cells are a group of CD3+ T cells sharing
characteristics of NK and T cells and constitute a major component of host anti-tumor …