Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …

Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …

Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …

Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the
brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the …

Recent advancements in gene supplementation therapy are expanding the options for the
treatment of neurological disorders. Among the available delivery vehicles, adeno …

A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision
access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in …

Viruses have evolved the ability to bind and enter cells through interactions with a wide
variety of cell macromolecules. We engineered peptide-modified adeno-associated virus …

Genetic intervention is increasingly being explored as a therapeutic option for debilitating
disorders of the central nervous system. The safety and efficacy of gene therapies rely upon …

Therapeutic payload delivery to the central nervous system (CNS) remains a major
challenge in gene therapy. Recent studies using function-driven evolution of adeno …

Delivering genes to and across the brain vasculature efficiently and specifically across
species remains a critical challenge for addressing neurological diseases. We have evolved …